Real • Unique Formula® Cardiovascular Health

Refer to the US National Institutes of Health (NIH) – PMCID: PMC4317477, PMID: 25671065 – Consumption of black garlic extract lowers SREBP-1C mRNA expression, which causes downregulation of lipid and cholesterol metabolism. As a result, the blood levels of total lipids, triglyceride (TG), and cholesterol were decreased. In this study, black garlic extract significantly increased the fecal excretion of lipids, both TG and cholesterol, and the absorption rate of dietary fat, resulting in a significant reduction in the plasma concentration of lipid profiles in rats fed black garlic extract. Thus, appropriate intake of black garlic will be beneficial in the prevention of hyperlipidemia and hyperglycemia caused by a high fat diet.

The main constituents of black garlic extract are water soluble compounds; thus, it lacks the toxicity and has no peculiar garlic smell. Therefore, it can be taken by humans for a long time without presenting toxic side effects or contraindications with medications to prevent or reduce hyperlipidermia.

Black Garlic Extract is a rich source of antioxidants, vitamins, and minerals. It contains nearly 10 times more allicin than fresh garlic. Allicin is known for its medicinal properties. It helps promote digestive and colon health, supports heart health, contributes to liver health, assists with maintaining a healthy weight, promotes brain health and supports cognition and memory. Black Garlic Extract also has natural anti-inflammatory properties that help fortify the immune system.

Beta-glucans are most commonly used for heart disease and high cholesterol. It might prevent the body from absorbing cholesterol from food. They might also stimulate theimmune systemby increasing chemicals that prevent infections. Refer to the US National Institutes of Health (NIH) – PMC5249102 Beta-Glucans Supplementation Associates with Reduction in P-Cresyl Sulfate Levels and Improved Endothelial Vascular Reactivity in Healthy Individuals. Moreover, beyond reducing LDL and total cholesterol, beta-glucans treatment is associated with an amelioration of the endothelial function.

Lecithin is a mixture of various phospholipids, and the composition depends on the origin of the lecithin. A major source of lecithin is soybean oil.

Refer to the US National Institutes of Health (NIH); National Library of Medicine PMCID: PMC3065734 – Atherosclerosis, the most serious cardiovascular disease, may affect individuals at an early age (20–29). Recent studies suggest that after taking soy lecithin capsule daily, the results showed a reduction of 40.66% and 42.00% in total cholesterol and of 42.05% and 56.15% in LDL cholesterol after treatment for one and two months, respectively. Therefore, it is recommended that the administration of soy lecithin daily may be used as a supplemental treatment in hypercholesterolemia.

The Food and Drug Administration-(FDA) USA, and the World Federation of Cardiology recommended daily use of soy protein to prevent cardiovascular disease.

According to the US National Institutes of Health (NIH) PMID: 17147561, Niacin and niacinamide are similarly effective as a vitamin because they can be converted into each other within the organism. The blanket term vitamin B(3) is used for both. Niacinamide is a component of important coenzymesinvolved in hydrogen transfer.It is one of the precursor of NAD and NADP-is critical for mitochondrial function, and its supplementation can lead to increased longevity – Refer to cience.org, VOL. 352, NO. 6292:NAD REPLETION IMPROVES MITOCHONDRIAL AND STEM CELL FUNCTION AND ENHANCES LIFE SPAN IN MICE.

Refer to the US NIH: PMC 4793528 : L-Arginine, is a conditionally essential amino acid, is the main substrate of nitric oxide synthase (NOS) family enzymes and is responsible for the production of the endothelium-derived relaxing factor nitric oxide (NO), which is involved in regulatory mechanisms of the cardiovascular system.   Therefore, L-arginine has a potentially protective effect in regulating blood pressure and prevention of CHD.

Refer to the US National Institute of Health(NIH)  PMID: 31336573 PMCID: PMC6683098 – The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure – It revealed that oral administration of the amino acids l-arginine (Arg) and l-citrulline (Cit), which are potential substrates for eNOS, could effectively reduce Blood Pressure  by increasing Nitric Oxide production. Both Arginine and Citrulline are effective at increasing plasma Arginine, it is approximately twice as potent, which is most likely due to a lower first-pass metabolism.

The current data suggest that oral Arg supplementation can lower BP by 5.39/2.66 mmHg, which is an effect that is comparable with diet changes and exercise implementation. The antihypertensive properties of Cit are more questionable, but are likely in the range of 4.1/2.08 to 7.54/3.77 mmHg. The exact mechanism by which Cit and Arg exert their effect is not fully understood, as normal plasma Arg concentration greatly exceeds the Michaelis constant (Km) of eNOS. Thus, elevated plasma Arg concentrations would not be expected to increase endogenous NO production significantly, but have nonetheless been observed in other studies. This phenomenon is known as the “l-arginine paradox”.

Nitric Oxide it contributes to the regulation of cardiac contractility and dilates blood vessels, leading to increased blood supply and decreased Blood Pressure. Nitric oxide (NO) is a well-known vasodilator produced by the vascular endothelium via the enzyme endothelial nitric oxide synthase (eNOS). The inadequate production of NO has been linked to elevated blood pressure (BP) in both human and animal studies, and might be due to substrate inaccessibility.

Hypertension is a state of elevated systolic and/or diastolic blood pressure. For years, blood pressure (BP) equal to or higher than 140/90 mmHg was classified as hypertension, but the 2017 updated guidelines from the American College of Cardiology and American Heart Association classified hypertension as BP equal to or higher than 130/80 mmHg. An optimal blood pressure level is a reading under 120/80 mmHg. Hypertension is a known risk factor for many diseases, including stroke, myocardial infarction, and renal disease .

It’s an amino acid naturally produced by the body, It boosts nitric oxide production in the body. Nitric oxide helps your arteries relax and work better, which improves blood flow throughout your body. This may be helpful for treating or preventing some diseases.

Omega-3 fatty acids are “healthy fats” Omega-3 fatty acids have many potential benefits for your cardiovascular health. One key benefit is that they help lower your triglyceride levels. Too many triglycerides in blood (hypertriglyceridemia) raises the risk of atherosclerosis, and through this, can increase the risk of heart disease and stroke. So, it’s important to keep triglyceride levels under control. In addition, omega-3s may help to arising HDL (good) cholesterol and lowering blood pressure. Fish oil are known to have blood-thinning effects that reduce blood viscosity and reduce the risk of blood vessel blockages.

Niacin also known as nicotinic acid and vitamin B3, is a water soluble, essential B vitamin that, when given in high doses, is effective in lowering low density lipoprotein (LDL) cholesterol and raising high density lipoprotein (HDL) cholesterol, which makes this agent of unique value in the therapy of dyslipidemia.

Niacin is a very important drug in treating cholesterol problems, particularly people with elevated triglycerides and low HDL. In fact, it’s one of the best drugs out there that can raise your HDL levels.

CoQ10 is a naturally occurring antioxidant in the body that cells use for growth and maintenance. But levels of CoQ10 in the body decline with age. CoQ10 levels have also been found to be lower in people with certain conditions, such as heart disease, and in those who take cholesterol-lowering drugs called statins.

Refer to the US National Institute of Health (NIH) PMCID: PMC6131403 : COQ10 stops the initial process of lipid peroxyl radicals’ formation. That is the reason why COQ10 is considered to be a very potent antioxidant against ROS and free radicals in biological membranes.  Reactive Oxygen Species (ROS) can cause serious cellular damage by means of reacting with cell membranes, DNA and protein centers [14]. Besides that, the products of oxidative stress and cytokines may lead to hypertrophy because they trigger the growth of myocytes

COQ10 plays a great role in the heart’s energetic needs. For example, the process of cardiac contraction, which involves the release of Ca2+ from the sarcoplasmic reticulum and the following activation of the contractile proteins requires energy. There is a theory that myocardial failure may be caused by the reduced production of the energy in mitochondria. COQ10 is the main component in the transport of electrons necessary for ATP production.

Besides that, COQ10 possesses anti-inflammatory effect, because different cardiovascular diseases, for example, heart failure are related to chronic pro-inflammatory state, supposing increased circulating levels of cytokines and adhesion molecules. There are some new studies that establish anti-inflammatory properties of COQ10 possibly by means of nitric oxide’s regulation, and that mechanism may be effective in heart failure treatment. Thus, the cytokines’ and chemokines’ secretion wouldn’t induce myocardial fibrosis and lead to Heart Failure (HF) development.

It is considered that COQ10 adjusts the angiotensin effect in sodium retention and decreases the level of aldosterone [29]. This effect was proved in a study where COQ10 was administrated as an adjuvant to usual antihypertensive therapy.