Real • Unique Mood Sleep Rescue
Hectic lifestyles, stress, and medical conditions can contribute to poor sleep habits and disrupts your night slumber on occasion. In the U.S., millions of Americans struggle to fall asleep each night, including about 10 percent who suffer from chronic insomnia. This latter condition involves difficulty falling asleep and staying asleep, as well as waking up too early in the morning. Sleep inducers such as drugs and OTC medicines may often lead to dependence and other side effects.
Both sleep and emotional states involve complex physiological cycles in the body，and one or two medicinal ingredients cannot provide immediate relief or cure. Real House has focused on research and development, now introduces a remedy starting from easing tense, relaxing the body then lead you to a night of deep sleep. We know the mechanisms of human sleeping mode, our unique formula guide you a deep relaxation sleeping. Real House cares of your physiological and psychological state，This is Real Health!
*Note: Mood Sleep Rescue is not a sleeping pill, and does not put you to sleep immediately with 1 or 2 capsules. This is a health supplement that helps reduce stress, tension and anxiety, promotes relaxation, and improves the quality of sleep. Long-term use of this product may effectively optimize the sleep pattern.
Place of Production: Canada
Size: 90 vegetable capsules per bottle
Shelf Life: Three Years (if unopened). The product is safe to use for three years but for best effect, the product should be consumed as soon as possible after opening. Typically, our customers finish this product in 1-3 months after opening.
Recommended Dose: Adults: 2 capsule(s), 1 time(s) per day. Take 30-45 minutes before bedtime. Take with food. Take an earlier dose during the evening if necessary.
Recommended Use: Used as a sleep aid. Helps to promote healthy mood balance. Herbal Medicine helps relieve restlessness and/or nervousness (calmative). Helps to temporarily promote relaxation and to improve sleep quality and mental focus. Helps to reduce the severity and duration of migraine headaches when taken as a preventative. Helps to form red blood cells and maintain the normal function of the immune system and the energy metabolism.
Supplement Facts （Each vegetable capsule contains）
|Tryptophan ((S)-alpha-Amino-1H-indole-3-propanoic acid)||30 mg|
|gamma-Aminobutyric acid (GABA)||30mg|
|L-5-HTP (5-Hydroxy-L-tryptophan, 5-HTP, Griffonia simplicifolia – Seed)||100mg|
|Suan zao ren (Ziziphus jujuba var. spinosa, Seed)||30mg (3:1, QCE 90mg)|
|Valerian Root (Valeriana officinalis, Roots)||100mg (5:1, QCE 500mg)|
|Magnolia Bark (Magnolia officinalis, Stem bark)||30mg (4:1, QCE 120mg)|
|Vitamin B3 (Niacin)||10mg|
|Vitamin B6 (Pyridoxal 5’-phosphate)||5mg|
|Vitamin B5 (Pantothenic acid, D-Pantothenic acid)||10mg|
|Vitamin B9 (Folate)||200μg|
|Vitamin B12 (Methylcobalamin)||600μg|
|Glycine (Aminoacetic acid, Glycine, Arthrospira maxima-Whole)||30mg|
Non-medicinal ingredients: Rice flour, Microcrystalline cellulose, Hypromellose.
Major Ingredients and Functions:
It is known as an “essential” amino acid because the body does not produce it. Tryptophan is important to the functions of many organs in the body. When you consume tryptophan, your body absorbs it and changes it to eventually become a hormone called serotonin. Serotonin transmits signals between your nerve cells. The amount of serotonin in the brain can affect mood. Other uses not proven with research include treating sleep problems (insomnia), anxiety, depression, and attention deficit hyperactivity disorder (ADHD).
Refer to the US National Library of Medicine National Institutes of Health: J Am Coll Nutr. 2015;34(5):436-47. DOI: 10.1080/07315724.2014.926153. Epub 2015 Mar 11. L-Theanine (γ-glutamylethylamide). This water-soluble essential amino acid can cross the blood-brain barrier and provides anxiolytic effects via the induction of α brain waves without additive and other side effects associated with conventional sleep inducers. Anxiolysis is required for the initiation of high-quality sleep. Studies suggest that the administration of L-theanine before bed may support improved sleep quality not by sedation but through anxiolysis. L-Theanine promotes relaxation without drowsiness. This review suggests that L-theanine is a safe natural sleep aid.
L-Theanine works primarily by modulating levels of various brain chemicals, increases levels of the calmative neurotransmitters dopamine, serotonin, and GABA, all of which are important for regulating mood, alertness, sleep, and energy.
In fact, in 1986, a review of the literature was published using L-Tryptophan as a therapeutic supplement for insomnia. The authors concluded that L-Tryptophan could be used effectively to induce sleep.
It easily crosses the blood-brain barrier and effectively increases the central nervous system (CNS) synthesis of serotonin. In the CNS, serotonin levels have been implicated in the regulation of sleep, depression, anxiety, aggression, appetite, temperature, sexual behavior, and pain sensation.
Our bodies convert it to 5-HTP (5-hydroxytryptophan), and then to serotonin, melatonin, and vitamin B6 (nicotinamide). Serotonin is a hormone that transmits signals between nerve cells. Changes in the level of serotonin in the brain can alter the mood. Melatonin is important for sleep and vitamin B6 is essential for energy metabolism.
GABA (Gamma-aminobutyric acid)
GABA is a neurotransmitter that sends chemical messages through the brain and the nervous system and is involved in regulating communication between brain cells. It inhibits nervous system activity, producing a relaxation effect. They slow down the body’s central nervous system and cause sleepiness。
GABA plays an important role in behavior, cognition, and the body’s response to stress. Lower-than-normal levels of GABA in the brain have been linked to schizophrenia, depression, anxiety, and sleep disorders.
Another study, this one published in 2016, also found sleep-promoting benefits from a combination of GABA and 5-HTP, including improving the time to fall asleep, sleep duration, and sleep quality.
Recent research showed that natural GABA had various sleep-improving effects. The researchers measured brain waves using electroencephalography (EEG). Those who took GABA fell asleep faster and had longer quality sleep time. They also reported feeling more energized in the morning.
Valerian has a very long history of use; it has been taken to treat insomnia, nerve conditions like anxiety and restlessness dating back to the second century and in Europe, , it has been approved in Germany as a mild sedative and regarded as generally safe by the food and drug administration in the United States. In 1953, valerian tablets passed the European green non-toxic drug certification and were included in the European pharmacopeia.
In one double-blind study conducted by the Foellinge Health Center in Sweden, the effects of valerian on poor sleep were significant. Of the study participants, 44 percent reported perfect sleep while 89 percent reported improved sleep when taking valerian root.
Scientists have found that valerian root increases the amount of a chemical called gamma-aminobutyric acid (GABA) through GABA receptors. GABA helps regulate nerve cells and calms anxiety
Studies show that valerian reduces the time it takes to fall asleep and improves sleep quality, Unlike many prescription sleep medications, valerian has fewer side effects and is a lot less likely to result in morning drowsiness.
It functions principally within the brain stem and spinal cord where it facilitates the transmission of nerve impulses. This amino acid interferes with the hyper-excitability of the central nervous system neurons. It does this by removing chloride and potassium to regulate their ability to be over stimulated。 There have been numerous studies investigating the benefits of this amino acid in the treatment of disorders such as hyperactivity, schizophrenia, bipolar, and epilepsy. In a 2007 study published in the journal “Sleep and Biological Rhythms,” investigators found that glycine supplementation improved both subjective and objective measures of sleep quality in patients who experienced continuously unsatisfactory sleep.
Suan Zao Ren
Suan Zao Renis the seed of the sour jujube date. Experiments in animals support the presence of anxiolytic and sedative properties. It is commonly used in Chinese herbal formulas to address insomnia coupled with anxiety and nervousness, heart palpitations (i.e. feeling the heart flutter in one’s chest), and/or irritability, doing so by nourishing the Heart and Liver. This gives these two organ systems more resources to deal with stress and consequently helps them to relax, feel less anxious, and improve the quality of sleep.
Main chemical constituents are Glycoside saponins, alkaloids, sanjoinenine, triterpenoids, flavonoids, 17 kinds of amino acids, a variety of metallic elements (potassium, sodium, calcium, zinc, iron, copper, manganese, etc.), ferulic acid, vitamin C, plant sterols and short-medium chain fatty acids, etc.
The traditional medications for insomnia and depression in western medicine are quite addictive and with lots of side effects. In comparison, Chinese herbs for insomnia and depression are not addictive and won’t result in drug dependence. Jujube seeds can effectively help relieve insomnia naturally, improve sleep quality, and relieve headaches, dizziness, fatigue, and other phenomena. More importantly, it helps people sleep sound again, in a natural way.
(instead of other magnesium supplements, magnesium glycinate as the body finds it easier to absorb in this form).
Magnesium is an essential mineral, one of seven essential macro-minerals that the human body needs in large quantities. The body does not produce magnesium. Healthy magnesium levels protect metabolic health, stabilize mood, keep stress in check, promote better sleep, and contribute to heart and bone health. Magnesium important roles is as an enabler of healthy enzyme function. Magnesium is involved in more than 300 different enzyme-related reactions in the body’s cells. Magnesium plays a role in supporting deep, restorative sleep by maintaining healthy levels of GABA, a neurotransmitter that promotes sleep. Magnesium can also help insomnia and link to Stress reduction and mood stabilization.
Dr. Hotze states that magnesium is a key element in the production of serotonin in your brain. Because serotonin is a mood elevator, a lack of it can cause depression, a symptom of which is insomnia
Some publication has shown that magnesium deficiency may be a trigger for anxiety and nervousness. Research shows that taking magnesium glycinate may promote a calming effect and help to reduce symptoms of anxiety and may promote the quality of sleep.
Inositol is an essential component of cell membranes and plays an important role in cell growth and brain function. It affects chemical messengers in your brains, such as serotonin and dopamine。It helps balance important chemicals in the human brain, including those believed to affect your mood, such as serotonin and dopamine (4Trusted Source). Interestingly, researchers have found that some people with depression, anxiety, and compulsive disorders have lower levels of inositol in the brain。Inositol is a carbocyclic sugar that is abundant in the brain and other mammalian tissues mediate cell signal transduction in response to a variety of hormones, neurotransmitters and growth factors。
Many studies have been conducted regarding the inositol’s effects on different human biological functions. Consider the following research highlighting inositol’s possible ability to work for patients with panic disorder:
- American Journal of Psychiatry (1995) — This study showed that the frequency and severity of panic attacks and agoraphobia lessened significantly after inositol administration, with minimal side effects. The authors concluded that inositol may be a potential therapeutic for panic disorder.
- Journal of Clinical Psychopharmacology (2001) — During the first month of the study, it was discovered that inositol helped reduce the number of panic attacks experienced by patients.
Inositol plays a structural role in your body as a major component of cell membranes.
Magnolia bark has long been regarded as a potent anxiolytic (anxiety-relieving) drug. According to a 2013 review of studies in the journal Frontiers, honokiol functions as a depressant the central nervous system while interacting with the same receptors in the brain—called gamma-aminobutyric acid (GABA) receptors—that certain antidepressants and benzodiazepine drugs do.
According to research, honokiol appears as nearly effective as the benzodiazepine drug Valium (diazepam) in relieving anxiety but with far fewer motor and cognitive side effects.2
With the said, the results can vary based on the magnolia bark extract used. Efforts are now underway to explore the pharmaceutical potential of purified honokiol and magnolol in treating insomnia, stress, depression, and other mood-related disorders.
According to studies A mixture of honokiol and magnolol (the two compounds in magnolia bark) was found to offer antidepressant benefits,. These two compounds also increase the serotonin levels in the prefrontal cortex, the low levels of which are linked to depression
By lowering cortisol levels, magnolia bark relaxes the body and the mind. Taking this herb right before you go to bed can help combat sleeplessness as it promotes rapid drowsiness. Ensure you don’t take it during the day or while driving or operating heavy machinery – for obvious reasons.
Vitamin B Group
Vitamins are a group of water-soluble micronutrients that play an important role in cell metabolism and many other important bodily functions。 It also plays a role in improving symptoms of insomnia
Vitamin B3 (niacin) often promotes sleep in people who have insomnia caused by depression and increases the effectiveness of tryptophan. Specifically, niacin is a major component of NAD and NADP, two coenzymes involved in cellular metabolism. Furthermore, it plays a role in cell signaling and making and repairing DNA, in addition to acting as an antioxidant。
Symptoms of niacin deficiency: Fatigue, Depression, Headache, Diarrhea
Vitamin B5 (pantothenic acid) is good for relieving stress and anxiety. A deficiency of B5 can cause sleep disturbances and fatigue.
Vitamin B6 in coenzyme forms performs a wide variety of functions in the body and is extremely versatile, with involvement in more than 100 enzyme reactions, mostly concerned with protein metabolism。Vitamin B6 also plays a role in cognitive development through the biosynthesis of neurotransmitters and in maintaining normal levels of homocysteine, an amino acid in the blood。Vitamin B6 is involved in gluconeogenesis and glycogenolysis, immune function (for example, it promotes lymphocyte and interleukin-2 production), and hemoglobin formation。Several studies have demonstrated an association between vitamin B6 and brain function in the elderly.
Vitamin B9 (folic acid) is not only protected developing babies against certain birth defects but also supports healthy brain development through the teenage years, researchers report. Folate is effective to maintain normal brain development and function. Folate deficiency has been linked to insomnia.
Vitamin B12 (cobalamin) benefits the central nervous system in many important ways: It helps maintain the health of nerve cells-including those needed for neurotransmitter signaling- and helps form the protective covering of nerves, called the cell’s myelin sheath.
It is reported the vitamin B12 helps insomniacs who have problems falling asleep, as well as promoting normal sleep-wake cycles.
A deficiency in any of the B-Vitamins can lead to early signs of insomnia and even anxiety and depression.
Caution and Warnings:
1) Not to use if you’re taking other medications that increase serotonin levels, such as antidepressants like SSRIs and MAO inhibitors. Use caution when taking Carbidopa, a medication for Parkinson’s disease.
2) This not recommended for people with Down syndrome, as it has been linked to seizures.
3) don’t take it less than two weeks before surgery as it may interfere with some drugs commonly used during surgical procedures.
4) Pregnancy and breast-feeding are better to stay on the safe side and avoid use.
5) Consult a health care provider/professional/doctor if sleeplessness persists continuously for more than 4 weeks (Chronic insomnia); and/or taking diuretics, heart medicines, or antibiotics; and for use this product beyond 1 year.
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